IL6ST Rabbit pAb, Unconjugated, Polyclonal
Artikelnummer:
ABB-A14656
- Bilder (1)
| Artikelname: | IL6ST Rabbit pAb, Unconjugated, Polyclonal |
| Artikelnummer: | ABB-A14656 |
| Hersteller Artikelnummer: | A14656 |
| Alternativnummer: | ABB-A14656-100UL,ABB-A14656-1000UL,ABB-A14656-500UL,ABB-A14656-20UL |
| Hersteller: | ABclonal |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC-P, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | CD130, GP130, HIES4, IMD94, STWS2, CDW130, HIES4A, HIES4B, IL-6RB, sGP130, IL6ST |
| The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
| Klonalität: | Polyclonal |
| Molekulargewicht: | 104kDa |
| NCBI: | 3572 |
| UniProt: | P40189 |
| Reinheit: | Affinity purification |
| Sequenz: | PSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ |
| Target-Kategorie: | IL6ST |
| Application Verdünnung: | WB,1:500 - 1:2000|IHC-P,1:50 - 1:100|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Anwendungsbeschreibung: | Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Cancer,Signal Transduction,Cell Biology Developmental Biology,Apoptosis,Immunology Inflammation,CDs,Cytokines,Jak-Stat-IL-6 Receptor Signaling Pathway,Cardiovascular,Heart,Hypertrophy. Shipping: Ice Bag |
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Western blot analysis of lysates from Mouse liver, using IL6ST Rabbit pAb (A14656) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
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