Alpha-2-Macroglobulin (A2M) Rabbit pAb, Unconjugated, Polyclonal
Artikelnummer:
ABB-A1573
- Bilder (1)
| Artikelname: | Alpha-2-Macroglobulin (A2M) Rabbit pAb, Unconjugated, Polyclonal |
| Artikelnummer: | ABB-A1573 |
| Hersteller Artikelnummer: | A1573 |
| Alternativnummer: | ABB-A1573-100UL,ABB-A1573-20UL,ABB-A1573-1000UL,ABB-A1573-500UL |
| Hersteller: | ABclonal |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | A2MD, CPAMD5, FWP007, S863-7, Alpha-2-Macroglobulin (A2M) |
| The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimers disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. |
| Klonalität: | Polyclonal |
| Molekulargewicht: | 163kDa |
| NCBI: | 2 |
| UniProt: | P01023 |
| Reinheit: | Affinity purification |
| Sequenz: | ALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE |
| Target-Kategorie: | A2M |
| Antibody Type: | Primary Antibody |
| Application Verdünnung: | WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Anwendungsbeschreibung: | Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Cell Biology Developmental Biology,Ubiquitin,Cardiovascular,Blood,Serum Proteins. Shipping: Ice Bag |
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Western blot analysis of various lysates, using Alpha-2-Macroglobulin (A2M) Rabbit pAb (A1573) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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