Myelin Protein Zero (MPZ) Rabbit mAb, Unconjugated, Monoclonal
Artikelnummer:
ABB-A21931
- Bilder (1)
| Artikelname: | Myelin Protein Zero (MPZ) Rabbit mAb, Unconjugated, Monoclonal |
| Artikelnummer: | ABB-A21931 |
| Hersteller Artikelnummer: | A21931 |
| Alternativnummer: | ABB-A21931-100UL,ABB-A21931-20UL |
| Hersteller: | ABclonal |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC-P, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | P0, CHM, DSS, MPP, CHN2, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, HMSNIB, Myelin Protein Zero (MPZ) |
| This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. |
| Application Verdünnung: | WB,1:2000 - 1:20000|IHC-P,1:500-2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements. |
| Anwendungsbeschreibung: | Cross-Reactivity: Mouse,Rat. ResearchArea: Neuroscience, Cell Type Marker,Neurodegenerative Diseases,Neuron marker. Shipping: Ice Bag |
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Western blot analysis of various lysates using Myelin Protein Zero (MPZ) Rabbit mAb (A21931) at1:19000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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