Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Konjugation:
ABflo 488
Alternative Synonym:
SAF2, SIGLEC-8, SIGLEC8L
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM, MIM 603492) that mediates an association with SLAM-associated protein (SAP, MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
Cross-Reactivity: Human. ResearchArea: Signal Transduction,Cell Biology Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology Inflammation,CDs. Shipping: Ice Bag
Flow cytometry:1X10 6 293F cells (negative control,left)and 293F(Transfection,right) cells were surface-stained with ABflo 488 Rabbit anti-Human Siglec-8 mAb(A22189,5 µl/Test,orange line) or ABflo 488 Rabbit IgG isotype control (A22069,5 µl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
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