Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12) FITC Conjugated
Artikelnummer:
ABI-10-1003-F
Hersteller Artikelnummer:
10-1003-F
Alternativnummer:
ABI-10-1003-F-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS
Spezies Reaktivität:
Human
Immunogen:
Full length recombinant Caspase-3 protein was used as the immunogen for this antibody.
Konjugation:
FITC
Alternative Synonym:
Casp3, Cpp32
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimers disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
Fig-1:Intracellular FLOW cytometric analysis of Caspase 3 (Clone : ABM1C12) on Jurkat cells using 0.5 µg of antibody. Green represents FITC conjugated IgG1 isotype control (ABEOMICS), red represents FITC conjugated anti-caspase 3 (10-1003-F) antibody.
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