A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.
Alternative Synonym:
TLR6
TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5-1 µg/10 6 cells
Fig-1: Intracellular flow analysis of TLR6 in THP-1 cells using 0.5 µg/10 6 cells of TLR6 antibody (Clone: ABM1B50). Green represents isotype control, red represents anti-TLR6 antibody. Goat anti-Mouse PE conjugate was used as secondary antibody.
Fig-2: Western blot analysis of TLR6. Anti- TLR6 antibody (Clone: ABM1B50) was used at 2 µg/ml on Jurkat lysate.
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