A partial length recombinant TLR3 protein (amino acids 25-370) was used as the immunogen for this antibody.
Alternative Synonym:
TLR3
TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
Fig-1: Intracellular flow analysis of TLR3 in human PBMC (lymphocytes) using 2.0 µg/10 6 cells of TLR3antibody (Clone: ABM15D5). Green represents isotype control, red represents anti-TLR3 antibody. Goat anti-mouse PE conjugate was used as secondary.
Fig-2: Intracellular flow analysis of TLR3 in human Jurkat using 0.5 µg/10 6 cells of TLR3 antibody (Clone: ABM15D5). Green represents isotype control, red represents anti-TLR3 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
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