A full length recombinant FOXO1 protein was used as the immunogen for this antibody.
Alternative Synonym:
FOXO1||FKHR||FOXO1A
FOXO1 is one of the fox proteins playing pivotal roles in several human intracellular pathways. These proteins are transcription factors acting as nuclear regulator of transcriptional activity of a number of metabolic processes such as the cellular response to oxidative stress. FOXO1 protein response to oxidative stress may be linked to Alzheimers disease (AD) by means of insulin brain resistance. FOXO1 plays a critical role in establishing and maintaining the B cell specific differentiation program, but it is also responsible for cell death due to an inappropriate BCR signaling. This protein is highly expressed in B cells, is downregulated in Hodgkin and Reed-Sternberg (HRS) cells of cHL (Classical Hodgkin Lymphoma).
Western blot analysis: 2-4 µg/ml, FACS: 0.5-1 µg/10 6 cells
Fig-1: Western blot analysis of FOXO1. Anti-FOXO1 antibody (Clone: ABM4E66) was tested at 2 µg/ml on Jurkat lysate.
Fig-2: Intracellular FLOW analysis of THP1 cells using 0.5 ug of Anti-FOXO1 antibody (Clone: ABM4E66). Goat Anti-Mouse FITC was used as secondary antibody. Green represents Isotope control (ABEOMICS), red represents AntiFOXO1 antibody.
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