Polyclonal Antibody to TRK Fused gene
Artikelnummer:
ABI-11-8031
- Bilder (3)
| Artikelname: | Polyclonal Antibody to TRK Fused gene |
| Artikelnummer: | ABI-11-8031 |
| Hersteller Artikelnummer: | 11-8031 |
| Alternativnummer: | ABI-11-8031-100UG |
| Hersteller: | Abeomics |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody. |
| Alternative Synonym: | TFG |
| TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation. |
| Application Verdünnung: | Western blot analysis:1-2 µg/ml, Immunohistochemical analysis: 20 µg/ml |
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Fig-1: Western blot analysis of TRK Fused gene. Anti-TRK Fused gene antibody (11-8031) was used at 1 µg/ml on (1) h Intestine and (2) h Kidney lysates. |
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Fig-2: Immunohistochemical analysis of TRK Fused gene. Anti-TRK Fused gene antibody (11-8031) in human Kidney tissue at 20 µg/ml. |
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Fig-3: Immunohistochemical analysis of TRK Fused gene. Anti-TRK Fused gene antibody (11-8031) in human Small Intestine tissue at 20 µg/ml. |
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