Polyclonal Antibody to PKC Theta (Phospho-Ser676), Rabbit
Artikelnummer:
ABI-35-1270
Hersteller Artikelnummer:
35-1270
Alternativnummer:
ABI-35-1270-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around phosphorylation site of serine 676 (R-L-S(p)-F-A) derived from Human PKCth.
Alternative Synonym:
KPCT|| PKC-theta|| PKCQ|| PRKCQ|| PRKCT
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. Kristof Van Kolen, et al. (2006) FEBS J , 273: 1843 - 1854. Martin Villalba, et al. (2002) J. Cell Biol , 157: 253. Jie Zhang, et al. (2004) J. Biol. Chem , 279: 22118 - 22123. Castro AF, et al. (1998) Am J Physiol Cell Physiol, 275: C113 - C119.
