NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NF-KB1/p105, NF-KB1/p50, REL and NF-KB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
Klonalität:
Polyclonal
Formulierung:
Purified
Target-Kategorie:
NF-KB-p105/p50 (Ab-337)
Application Verdünnung:
Predicted MW: 50 120 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
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