Peptide sequence around aa.306~310 (M-K-T-F-C) derived from Human AKT1.
Alternative Synonym:
RAC-PK-alpha|| Protein kinase B
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at Ser-939 and Thr-1462, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Tremblay F, et al. (2005) Diabetes, 54(9): 2674-84. Xu BE, et al. (2005) J Biol Chem, 280(40): 34218-23. Samuels Y, et al. (2005) Cancer Cell, 7(6): 561-73. Di Maira G, et al. (2005) Cell Death Differ, 12(6): 668-77.
