Peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.
Alternative Synonym:
ICA1|| ICAM1
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Greenwood J, et al. (2003) J Immunol, 171(4):2099-2108. Zhou Z, et al. (2005) Eur J Pharmacol, 513(1-2):1-8. Chen YH, et al. (2001) J Cell Biochem, 82(3):512-521
