Peptide sequence around aa.21~25 (L-G-T-G-G) derived from Human IKK a.
Alternative Synonym:
I kappa-B kinase alpha|| I-kappa-B kinase 1|| IKK-A|| IKK-alpha|| IKK1
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NF-KB2/p100 associated with RelB, inducing its proteolytic processing to NF-KB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates Ser-10 of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
