Peptide sequence around aa.254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A.
Alternative Synonym:
FOXO1
FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 Gan L, et al. (2005) J Neurochem, 93(5): 1209-19. Smith WW, et al. (2005) J Cell Biol, 169(2): 331-9. Di Maira G, et al. (2005) Cell Death Differ, 12(6): 668-77. Horn S, et al. (2004) Leukemia, 18(11): 1839-49. Zhao X, et al. (2004) Biochem J 4, 378(Pt 3): 839-49.
