Peptide sequence around aa.29~33 (T-P-Y-S-Y) derived from Human Paxillin.
Alternative Synonym:
Paxillin, Pxn
An antiphosphotyrosine antibody was used to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and a 76-kD protein was obtained that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells (Ref.1). This protein was purified from chicken gizzard smooth muscle, and was named Pxn (Paxillin) (paxillus means small stake or peg in Latin) as a protein tethered to the membrane at focal adhesions Davidson D, et al. (2001) EMBO J, 20(13): 3414-3426 Kook S, et al. (2000) Mol Biol Cell, 11(3): 929-939 Fleming I, et al. (1999) Proc Natl Acad Sci U S A, 96(3): 1123-1128 Goldberg MB, et al. (2001) Microbiol Mol Biol Rev, 65(4): 595-626 Thomas JT, et al. (1999) Proc Natl Acad Sci U S A, 96(15): 8449-8454
