Peptide sequence around aa. 1170~1174 (P-D-Y-Q-Q) derived from Human EGFR.
Alternative Synonym:
Receptor tyrosine-protein kinase ErbB-1
Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
