Polyclonal Antibody to PDGF Receptor beta (Ab-751), Rabbit
Artikelnummer:
ABI-35-1557
Hersteller Artikelnummer:
35-1557
Alternativnummer:
ABI-35-1557-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Rat
Immunogen:
Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.
Alternative Synonym:
PDGFR||PDGFR1
PDGF Receptor b encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor a and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
