Peptide sequence around aa. 1278~1282 (S-F-Y-Y-S ) derived from Human IGF-1R .
Alternative Synonym:
Insulin-like growth factor I receptor
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
