Peptide sequence around aa.72~76 (L-L-S-P-L) derived from Human Keratin 8 (CK8).
Alternative Synonym:
CK 8|| CK8|| CYK8|| Cytokeratin endo A|| K8
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
