Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Alternative Synonym:
PHLL1
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8. Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
