Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
Alternative Synonym:
ICE-like apoptotic protease 6
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
