Peptide sequence around aa.297~301( L-T-L-E-P) derived from Human Fibrillarin
Alternative Synonym:
FBL|| FIB|| FLRN|| RNU3IP1
Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
