Polyclonal Antibody to PI3 Kinase p85/p55(Ab-467/199), Rabbit
Artikelnummer:
ABI-35-1725
Hersteller Artikelnummer:
35-1725
Alternativnummer:
ABI-35-1725-100UL
Hersteller:
Abeomics
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa.465~469(L-Y-E-E-Y) derived from Human PI3 Kinase p85/p55.
Alternative Synonym:
p85||AGM7||p85-ALPHA||p55||p55-GAMMA
PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Stoyanov, B. et al. (1995) Science 269, 690-3. Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41. Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.
