Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
Alternative Synonym:
Signal transduction protein CBL|| Proto-oncogene c-CBL|| Casitas B-lineage lymphoma proto-oncogene|| RING finger protein 55
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
