Peptide sequence around aa.519~523(A-G-P-S-A) derived from Human NAC1
Alternative Synonym:
BEND8|| NACC1|| NAC-1|| BTBD14B|| FLJ37383
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Nakayama K., Nakayama N., Davidson B.,et al. Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006) NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor.
