Peptide sequence around aa.13~17(E-L-K-V-F) derived from Human DP-1
Alternative Synonym:
Dp-1|| TFDP1|| DRTF1
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis. Wu C.-L., Zukerberg L.R., Ngwu C., Harlow E., Lees J.A.Mol. Cell. Biol. 15:2536-2546(1995)
