Peptide sequence around aa.185~189(R-Y-K-V-D) derived from Human IGFBP-3.
Alternative Synonym:
IBP3|| BP-53
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Roghani M., Segovia B., Whitechurch O., Binoux M.Growth Regul. 1:125-130(1991) Ikonen M., Liu B., Hashimoto Y., Ma L. Cohen P.Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003) Zhou W., Ross M.M., Tessitore A. J. Proteome Res. 8:5523-5531(2009)
