Peptide sequence around aa.262~266(D-V-R-N-P) derived from Human CUEDC2.
Alternative Synonym:
C10orf66|| bA18I14.5
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. Zhang P.-J., Zhao J., Li H.-Y. EMBO J. 26:1831-1842(2007)
