Peptide sequence around aa.738~750 (A-A-E-T-L) derived Human from PSMA.
Alternative Synonym:
FGCP|| Folate hydrolase 1|| FOLH|| FOLH1|| GCP2
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4and isoform PSM-5would appear to be physiologically irrelevant. Involved in prostate tumor progression. Qin B et al. Identification of a LNCaP-specific binding peptide using phage display. Pharm Res 28:2422-34 (2011)
