Monoclonal Antibody to Topoisomerase (DNA) I, Mitochondrial (TOP1MT)(Clone : TOP1MT/488), Clone: [TOP1MT/488], Mouse
Artikelnummer:
ABI-36-1059
Hersteller Artikelnummer:
36-1059
Alternativnummer:
ABI-36-1059-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human TOP1MT protein
Alternative Synonym:
TOP1MT
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Flow Cytometry (0.5-1ug/million cells), ,Immunofluorescence (0.5-1ug/ml), Western Blot (0.5-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris wi
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