Monoclonal Antibody to Heparan Sulfate Proteoglycan (Large) / Perlecan(Clone : SPM255), Clone: [SPM255], Rat
Artikelnummer:
ABI-36-1249
Hersteller Artikelnummer:
36-1249
Alternativnummer:
ABI-36-1249-100UG
Hersteller:
Abeomics
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FACS, IF, IHC
Spezies Reaktivität:
Human, Mouse
Immunogen:
Murine EHS laminin prepaRation
Alternative Synonym:
HSPG2
This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min a
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