Monoclonal Antibody to CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)(Clone : 123A8, same 56C04), Clone: [123A8, same 56C04], Mouse
Artikelnummer:
ABI-36-1498
Hersteller Artikelnummer:
36-1498
Alternativnummer:
ABI-36-1498-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IF, IHC
Spezies Reaktivität:
Human
Immunogen:
Membrane prepaRation of a small cell lung carcinoma
Alternative Synonym:
NCAM1||NCAM
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20
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