A recombinant protein fragment containing the intracellular, transmembrane, and part of the extracellular domain of human podocalyxin
Alternative Synonym:
PODXL||PCLP||PCLP1
Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunoprecipitation (1-2ug/500ug protein), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating
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