Monoclonal Antibody to CD45RB (B-Cell Marker)(Clone : BRA-11, same as BRA-11G), Clone: [BRA-11, same as BRA-11G], Mouse
Artikelnummer:
ABI-36-1621
Hersteller Artikelnummer:
36-1621
Alternativnummer:
ABI-36-1621-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)
Alternative Synonym:
PTPRC||CD45
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM E
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