Monoclonal Antibody to Actin, Smooth Muscle (Leiomyosarcoma Marker)(Clone : 1A4, same as asm-1), Clone: [1A4, same as asm-1], Mouse
Artikelnummer:
ABI-36-1653
Hersteller Artikelnummer:
36-1653
Alternativnummer:
ABI-36-1653-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IF, IHC
Spezies Reaktivität:
Human, Mouse, Rat
Immunogen:
N-Terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH.
Alternative Synonym:
ACTA2||ACTSA||ACTVS||GIG46
Actin is a major component of the cytoskeleton and is present in most cell types. This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This MAb does not stain cardiac or skeletal muscle, however, it does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-4ug/ml), ,Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 4
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