Monoclonal Antibody to Thyroglobulin (Thyroidal Cell Marker)(6E1.), Clone: [6E1.], Mouse
Artikelnummer:
ABI-36-1720
Hersteller Artikelnummer:
36-1720
Alternativnummer:
ABI-36-1720-100UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
ELISA, IHC
Spezies Reaktivität:
Human
Immunogen:
Human thyroid follicular cells
Alternative Synonym:
TG
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA),Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml, 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&
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