A 17-amino acid synthetic peptide from the carboxyl-terminus of Rat TGF-alpha.
Alternative Synonym:
TGF-alpha
This antibody reacts with the C-terminus of TGF-alphaalpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with Ab-1 is completely blocked by the peptide used for raising this antibody. TGF-alpha(aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA,
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