Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)
Alternative Synonym:
Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor (GGF2), Heregulin-1, Heregulin, alpha (45kD, ERBB2 p185-activator), HGL, HRG1, HRGA, MST131, Neu Differentiation Factor (NDF), Neuregulin-1, NRG1, Sensory and Motor Neuron-Derived Fact
Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene throµgh alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
