Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody(Clone: PAPPA/2718), Clone: [PAPPA/2718], Mouse
Artikelnummer:
ABI-36-2895-20
Hersteller Artikelnummer:
36-2895-20
Alternativnummer:
ABI-36-2895-20-20UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
Alternative Synonym:
ASBABP2, Aspecific BCL2 ARE binding protein 2, Differentially placenta 1 expressed protein, DIPLA1, IGF-dependent, IGFBP4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease), PAPA, PAPP A, PAPPA1, Pappalysin-1, Pregnancy Associated Plasma Protein A (PAPP-A)
Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, althoµgh it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thoµght to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been sµggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been sµggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),
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