Anti-Calcineurin A / PPP3CA Monoclonal Antibody(Clone: CALNA/2353), Clone: [CALNA/2353], Mouse
Artikelnummer:
ABI-36-2994-20
Hersteller Artikelnummer:
36-2994-20
Alternativnummer:
ABI-36-2994-20-20UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human Calcineurin A protein
Alternative Synonym:
Calcineurin A alpha, Calcineurin A1, Calcineurin A, Calmodulin-dependent calcineurin A subunit alpha isoform, CALN, CALNA1, CAM-PRP catalytic subunit, CCN1, CNA alpha, CNA1, Ppp3ca, Protein phosphatase 2B catalytic subunit (PPP2B), Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform
Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),
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