Anti-Calcineurin B / PPP3R1 Monoclonal Antibody(Clone: BE2.1), Clone: [BE2.1], Mouse
Artikelnummer:
ABI-36-2996-20
Hersteller Artikelnummer:
36-2996-20
Alternativnummer:
ABI-36-2996-20-20UG
Hersteller:
Abeomics
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
ELISA, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human Calcineurin B protein
Alternative Synonym:
calcineurin B, type I (19kDa), Calcineurin subunit B type 1, CALNB1, Cna2, CNB, CNB1, Ppp3r1, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
ELISA (For coating, order antibody without BSA), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45
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