Recombinant fragment (around aa 214-339) of human HNF1A protein (exact sequence is proprietary)
Alternative Synonym:
Albumin proximal factor, Hepatic nuclear factor 1 alpha, Hepatic transcription factor 1 alpha, HNF-1A, Interferon production regulator factor, LFB1, LFB1 hepatic nuclear factor, Liver specific transcription factor LFB1, Maturity onset diabetes of the young 3 (MODY3), TCF1, Transcription factor 1 hep
HNF1A belongs to the homeobox protein family and is an essential transcription factor for many hepatic genes involved in detoxification, homeostasis and metabolisms of glucose, lipid, steroid and amino acid. In addition, HNF1A is an important component of the transcriptional networks governing embryonic pancreas development and differentiation. as well as maintaining the growth and function of islet cells in adult. HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas. Recently, genome-wide association studies have implicatedHNF1Aas a susceptibility gene for pancreatic cancer.
ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followe
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