CD20 Antibody [Clone B9E9], Clone: [B9E9], Mouse, Monoclonal
Artikelnummer:
ABT-AH10077-U0050
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| Artikelname: | CD20 Antibody [Clone B9E9], Clone: [B9E9], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH10077-U0050 |
| Hersteller Artikelnummer: | AH10077-U0050 |
| Alternativnummer: | ABT-AH10077-U0050-50UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20 |
| Recognizes a protein of 33-37kDa, identified as CD20 (Workshop V, Code CD20.12). B9E9 recognizes extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, B cell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in B-cell activation and cell cycle progression. |
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