CD33 Antibody [Clone WM53], Clone: [WM53], Mouse, Monoclonal
Artikelnummer:
ABT-AH10363-U0050
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| Artikelname: | CD33 Antibody [Clone WM53], Clone: [WM53], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH10363-U0050 |
| Hersteller Artikelnummer: | AH10363-U0050 |
| Alternativnummer: | ABT-AH10363-U0050-50UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67, CD33, CD33, SIGLEC3 |
| Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV, WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. |
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