CD95 / FAS / TNFRSF6 Antibody - With BSA and Azide, Clone: [B-R18], Mouse, Monoclonal
Artikelnummer:
ABT-AH11572-U0100
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| Artikelname: | CD95 / FAS / TNFRSF6 Antibody - With BSA and Azide, Clone: [B-R18], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH11572-U0100 |
| Hersteller Artikelnummer: | AH11572-U0100 |
| Alternativnummer: | ABT-AH11572-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, IHC-Fr |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6 |
| MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes. |
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