CD25 / IL2RA (Activated Lymphocyte Marker) Antibody - With BSA and Azide, Clone: [143-13], Mouse, Monoclonal
Artikelnummer:
ABT-AH11574-U0020
- Bilder (0)
| Artikelname: | CD25 / IL2RA (Activated Lymphocyte Marker) Antibody - With BSA and Azide, Clone: [143-13], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH11574-U0020 |
| Hersteller Artikelnummer: | AH11574-U0020 |
| Alternativnummer: | ABT-AH11574-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, CD25, IL2RA |
| Recognizes a protein of 55kDa, identified as CD25 (Workshop IV, Code A27). CD25 is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkinā€(TM)s disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R ļ chain, p75) and CD132 (common ļ chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and can effectively block IL-2 binding to CD25. |
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