CD11c (Dendritic Cell Marker) Antibody - With BSA and Azide, Clone: [ITGAX/1243], Mouse, Monoclonal
Artikelnummer:
ABT-AH11609-U0020
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| Artikelname: | CD11c (Dendritic Cell Marker) Antibody - With BSA and Azide, Clone: [ITGAX/1243], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH11609-U0020 |
| Hersteller Artikelnummer: | AH11609-U0020 |
| Alternativnummer: | ABT-AH11609-U0020-20UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF, IHC |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c, ITGAX, CD11C |
| Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues. |
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