CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: [CBT6], Mouse, Monoclonal
Artikelnummer:
ABT-AH12587-U0100
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| Artikelname: | CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide, Clone: [CBT6], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH12587-U0100 |
| Hersteller Artikelnummer: | AH12587-U0100 |
| Alternativnummer: | ABT-AH12587-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Human, Mouse |
| Alternative Synonym: | T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A |
| At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).Ā |
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