CD7 (T-Cell Leukemia Marker) Antibody - With BSA and Azide, Clone: [B-F12], Mouse, Monoclonal
Artikelnummer:
ABT-AH12623-U0100
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| Artikelname: | CD7 (T-Cell Leukemia Marker) Antibody - With BSA and Azide, Clone: [B-F12], Mouse, Monoclonal |
| Artikelnummer: | ABT-AH12623-U0100 |
| Hersteller Artikelnummer: | AH12623-U0100 |
| Alternativnummer: | ABT-AH12623-U0100-100UG |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, IF |
| Spezies Reaktivität: | Guinea pig, Human, Porcine |
| Alternative Synonym: | T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, CD7, CD7 |
| Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. |
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